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A molnupiravir-associated mutational signature in global SARS-CoV-2 genomes

We analysed global sequence databases to conclusively show that an antiviral drug called molnupiravir has resulted in viable SARS-CoV-2 viruses with significant numbers of mutations, in some cases with onwards transmission of mutated viruses.

Independent SARS-CoV-2 staff testing protected academic and health-care institutions in northwest London

ProteInfer: deep networks for protein functional inference

This work, completed as part of my residency at Google AI, uses deep residual networks to predict protein function from amino acid sequences. We show that these networks are able to perform this task effectively, in a way that complements BLAST-based approaches, and that they learn to place protein sequences into a generalised embedding space that facilitates downstream applications. Using TensorFlow JS, we built a tool that performs protein functional inference in the browser, client-side. The paper is presented in an interactive form that allows the reader to explore our work and try the models.

Regulators of male and female sexual development critical for transmission of a malaria parasite

Taxonium, a web-based tool for exploring large phylogenetic trees

Taxonium is the first tool to allow trees of millions of nodes to be readily explored in the browser.

Treenome Browser: co-visualization of enormous phylogenies and millions of genomes

Determinants of Spike infectivity, processing, and neutralization in SARS-CoV-2 Omicron subvariants BA. 1 and BA. 2

The origins and molecular evolution of SARS-CoV-2 lineage B. 1.1. 7 in the UK

Barcoding genetically distinct Plasmodium falciparum strains for comparative assessment of fitness and antimalarial drug resistance

CRISPR/Cas9 and genetic screens in malaria parasites: small genomes, big impact